The role of oxidative damage in mitochondria during aging: a review.

@article{Huang2004TheRO,
  title={The role of oxidative damage in mitochondria during aging: a review.},
  author={H. Huang and K. Manton},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2004},
  volume={9},
  pages={
          1100-17
        }
}
  • H. Huang, K. Manton
  • Published 2004
  • Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron transport chain plays an important role in energy production and is a significant source of ROS that… Expand
Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes.
TLDR
It is hypothesized that the electron leakage from complexes causes specific damage to their subunits and increased ROS generation as oxidative damage accumulates, leading to further mitochondrial dysfunction, a cyclical process that underlies the progressive decline in physiologic function seen in aged mouse kidney. Expand
Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes.
TLDR
It is postulate that the electron leakage from ETC complexes causes specific damage to their subunits and increased ROS generation as oxidative damage accumulates, leading to further mitochondrial dysfunction, a cyclical process that underlies the progressive decline in physiologic function of the aged mouse heart. Expand
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging
TLDR
The involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death. Expand
Degenerative diseases, oxidative stress and cytochrome c oxidase function.
TLDR
It is proposed that feedback inhibition of CcO by ATP keeps the membrane potential and ROS production at low levels, and is proposed to represent a missing molecular link between stress and degenerative diseases. Expand
Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes.
Age-associated mitochondrial dysfunction is a major source of reactive oxygen species (ROS) and oxidative modification to proteins. Mitochondrial electron transport chain (ETC) complexes I and IIIExpand
Reactive Oxygen Species: Friends and Foes of Signal Transduction
TLDR
The Journal of Signal Transduction presents a special issue on the involvement of ROS in physiological and pathological signal transduction processes from prokaryotes to low and high eukaryotes and the current understanding of this field is described. Expand
Autophagy and Aging: The Importance of Maintaining "Clean" Cells
TLDR
This work reviews the molecular defects responsible for the malfunctioning of two forms of autophagy - macroautophagy and chaperone-mediated autophage - in old mammals, and highlights general and cell-type specific consequences of dysfunction of the autophagic system with age. Expand
Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases.
  • L. Gao, K. Laude, H. Cai
  • Medicine, Biology
  • The Veterinary clinics of North America. Small animal practice
  • 2008
TLDR
The mitochondrial derived reactive oxygen species is involved in the pathogenesis of various clinical disorders including heart failure, hypoxia, ischemia/reperfusion injury, diabetes, neurodegenerative diseases, and the physiologic process of aging. Expand
Mitochondrial electron transport chain functions in long-lived Ames dwarf mice
TLDR
The data show that there are tissue specific mitochondrial functions that are characteristic of certain tissues of the long-lived Ames mouse and it is proposed that this may be a factor in the determination of extended lifespan of dwarf mice. Expand
Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements.
TLDR
Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 235 REFERENCES
Oxidative damage to mitochondria and aging
TLDR
Altered activity of electron transport chain complexes and increased release of reactive oxygen species from the mitochondria with age suggest that alterations in mitochondrial function occur with age as a consequence of increased oxidative damage. Expand
Oxidative damage and mitochondrial decay in aging.
TLDR
Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging. Expand
Mitochondrial role in cell aging
TLDR
The fine structural and biochemical data support the concept that the mitochondria of fixed postmitotic cells may be the site of intrinsic aging because of the attack by free radicals and lipid peroxides originating in the organelles as a by-product of oxygen reduction during respiration. Expand
Role of oxidative stress and protein oxidation in the aging process.
  • R. S. Sohal
  • Biology, Medicine
  • Free radical biology & medicine
  • 2002
TLDR
It is suggested that oxidative damage to proteins plays a crucial role in aging because oxidized proteins lose catalytic function and are preferentially hydrolyzed. Expand
Aging and protein oxidative damage
The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities ofExpand
Oxidative Damage and Mutation to Mitochondrial DNA and Age‐dependent Decline of Mitochondrial Respiratory Function a
TLDR
The respiratory enzymes containing the mutant mtDNA‐encoded defective protein subunits inevitably exhibit impaired respiratory function and thereby increase electron leak and ROS production, which in turn elevates the oxidative stress and oxidative damage of the mitochondria. Expand
Protein Oxidation
TLDR
The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases, most notably during aging. Expand
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging.
  • L. Yan, R. S. Sohal
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
Results of this study indicate that proteins in mitochondrial membranes are modified selectively during aging, and ANT was found to be the only protein in the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls. Expand
Mechanisms of aging: an appraisal of the oxidative stress hypothesis.
TLDR
It is concluded that although there is considerable evidence implicating oxidative stress in the aging process, additional evidence is needed to clearly define the nature of the involvement. Expand
Mitochondrial decay in aging.
TLDR
Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging. Expand
...
1
2
3
4
5
...