The role of oxidative damage in mitochondria during aging: a review.

  title={The role of oxidative damage in mitochondria during aging: a review.},
  author={Hai Huang and Kenneth G. Manton},
  journal={Frontiers in bioscience : a journal and virtual library},
  • Hai Huang, K. Manton
  • Published 1 May 2004
  • Biology
  • Frontiers in bioscience : a journal and virtual library
Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron transport chain plays an important role in energy production and is a significant source of ROS that… 
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    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
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