The role of oxidants and free radicals in reperfusion injury.

@article{Zweier2006TheRO,
  title={The role of oxidants and free radicals in reperfusion injury.},
  author={Jay L. Zweier and M. A. Hassan Talukder},
  journal={Cardiovascular research},
  year={2006},
  volume={70 2},
  pages={
          181-90
        }
}
While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage, reperfusion results in a unique form of myocardial damage. Functional alterations occur, including depressed contractile function and decreased coronary flow as well as altered vascular reactivity. Both myocardial stunning and infarction are seen. Over the last two decades, it has become increasingly clear that oxidant and oxygen radical formation is greatly increased in the post-ischemic heart and serves… CONTINUE READING

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