The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice.

@article{Kwon2010TheRO,
  title={The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice.},
  author={Hyo-Jung Kwon and Young-Suk Won and Won-Kee Yoon and Ki-Hoan Nam and Dae-Yong Kim and Sou Hyun Kim},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={242 3},
  pages={
          344-51
        }
}
Various epidemiological studies have shown that obesity increases the risk of liver disease, but the precise mechanisms through which this occurs are poorly understood. In the present study, we hypothesized that osteopontin (OPN), an extracellular matrix and proinflammatory cytokine, has an important role in making obese mice more susceptible to inflammatory liver injury. After exposure of genetically obese ob/ob and db/db mice to a single dose of d-galactosamine (GalN), the plasma liver enzyme… CONTINUE READING
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