The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions.

@article{Kovacsics2017TheRO,
  title={The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions.},
  author={Daniella Kovacsics and Izabel Patik and Csilla {\"O}zvegy-Laczka},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2017},
  volume={13 4},
  pages={409-424}
}
INTRODUCTION The in vivo fate and effectiveness of a drug depends highly on its absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Organic anion transporting polypeptides (OATPs) are membrane proteins involved in the cellular uptake of various organic compounds, including clinically used drugs. Since OATPs are significant players in drug absorption and distribution, modulation of OATP function via pharmacotherapy with OATP substrates/inhibitors, or modulation of their… CONTINUE READING
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