The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina

@article{Sangiovanni2005TheRO,
  title={The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina},
  author={John Paul Sangiovanni and Emily Y. Chew},
  journal={Progress in Retinal and Eye Research},
  year={2005},
  volume={24},
  pages={87-138}
}
In this work we advance the hypothesis that omega-3 (omega-3) long-chain polyunsaturated fatty acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina. omega-3 LCPUFAs may modulate metabolic processes and attenuate effects of environmental exposures that activate molecules implicated in pathogenesis of vasoproliferative and neurodegenerative retinal diseases. These processes and exposures… Expand
Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis.
TLDR
An overview of the biosynthetic pathways and biological properties of these omega-3 mediators is provided, with a particular focus on the emerging importance of the counter-regulatory role of Omega-3 and -6 fatty acids in the spatial and temporal regulation of the inflammatory response. Expand
The implication of omega-3 polyunsaturated fatty acids in retinal physiology
TLDR
This new and emerging concept based on the interrelationship of omega-3 PUFAs with neural and vascular structure and function appears to be essential when considering retinal diseases of public health significance such as age-related macular degeneration. Expand
Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases
TLDR
The current understanding of the n-3 fatty acids effects on the mechanisms of these retinal diseases and how they exert their therapeutic effects are summarized, focusing on ALA, EPA, DHA, and their metabolites. Expand
Effects of Omega-3 on Neurodegenerative Diseases and Stroke
TLDR
This chapter is an endeavor to summarize the state-of-the-art details of the neuroprotective effects of these fatty acids on Parkinson’s disease, Alzheimer's disease, and stroke through the review of both animal-model and human-based studies. Expand
Molecular Circuits of Resolution in the Eye
TLDR
Protective endogenous roles of LXA4 and NPD1 have been established utilizing lipidomic analysis, knockout mice, and pharmacological, genetic, and dietary manipulation, providing compelling evidence that these intrinsic lipid autacoid circuits play essential roles in restraining inflammation, promoting wound healing, inhibiting pathological angiogenesis, and providing neuroprotection in the delicate visual axis. Expand
ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases.
TLDR
Both of the ω-3 and the ψ-6 lipid products of cytochrome P450 oxidase 2C promote neovascularization in both the retina and choroid, which suggests that inhibition of this pathway might be beneficial. Expand
Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.
TLDR
Omega-3 fatty acid family member docosahexaenoic acid is avidly retained and uniquely concentrated in the nervous system, particularly in photoreceptors and synaptic membranes, and offers emerging targets for pharmaceutical intervention and clinical translation. Expand
The Role of Fish Oil in Inflammatory Eye Diseases
TLDR
Evidence from recent studies lends support to a role of fish oil in the treatment of two common inflammatory eye diseases - dry eye disease and age-related macular degeneration. Expand
5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids
TLDR
The authors found that protection against revascularization required 5-LOX, a non–heme iron dioxygenase that generates leukotrienes, lipoxins, and the recently identified ω-3 PUFA–derived resolvins and protectins. Expand
Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
TLDR
It is shown that increasing ω-3-PUFA tissue levels by dietary or genetic means decreased the avascular area of the retina by increasing vessel regrowth after injury, thereby reducing the hypoxic stimulus for neovascularization. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 465 REFERENCES
Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid.
TLDR
Recent data suggest that modulation of these VSMC functions contribute to the beneficial effects of n-3 PUFAs on various cardiovascular disorders, and strongly suggest that DHA has more potent and beneficial effects than EPA. Expand
(n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro.
TLDR
Findings support previous animal studies that suggest that (n-3) PUFA can influence immune reactivity by modulating antigen-presenting cell function. Expand
Polyunsaturated fatty acids, inflammation and immunity
TLDR
It is possible that these fatty acids might elicit some of their effects by eicosanoid-independent mechanisms, and may be of use as a therapy for acute and chronic inflammation, and for disorders which involve an inappropriately activated immune response. Expand
Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions.
TLDR
These findings establish new transcellular routes for producing arrays of lipid mediators via COX-2-NSAIDs and cell-cell interactions that impact microinflammation and provide novel mechanism(s) that could underlie the many reported therapeutic benefits of omega-3 dietary supplementation of interest in inflammation, cancer, and vascular disorders. Expand
Prostaglandins and other lipid mediators in Alzheimer's disease.
TLDR
This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD. Expand
Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells.
TLDR
Results of this study demonstrate that treatment with DHA down-regulates iNOS in parallel with a differential expression and down-regulation of IFNs, cyclic GMP, and nuclear factor kappa B isoforms, and indicate the presence of specific gene expression profiles in human colon cancer that can be used as molecular targets for chemopreventive agents. Expand
Fatty acid modulation of endothelial activation.
TLDR
Consumption of the n-3 fatty acid docosahexaenoic acid (DHA) reduced endothelial expression of vascular cell adhesion molecule 1 (VCAM-1) and reduced the adhesion of human monocytes and monocytic U937 cells to cytokine-stimulated endothelial cells, indicating a pretranslational effect. Expand
Omega-3 fatty acid lipid emulsion reduces LPS-stimulated macrophage TNF-alpha production.
TLDR
The contention that antiinflammatory effects of omega-3 FA occur at least in part through the inhibition of macrophage TNF-alpha production in response to endotoxin is supported. Expand
Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities.
TLDR
Interestingly, a progressive increase of the LPS-induced IL-1 beta gene expression and secretion among macrophages harvested from mice receiving the dietary supplement of saturated fatty acids is observed. Expand
The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease.
TLDR
The results indicate that n-3 FA supplementation decreases hemostatic markers of atherosclerosis, whereas markers of inflammation may be increased. Expand
...
1
2
3
4
5
...