The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma.

@article{Berenson2001TheRO,
  title={The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma.},
  author={James R Berenson and Hong Mei Ma and Robert A. Vescio},
  journal={Seminars in oncology},
  year={2001},
  volume={28 6},
  pages={626-33}
}
Increased nuclear factor (NF)-kappaB activity is associated with enhanced tumor cell survival in multiple myeloma (MM). The function of NF-kappaB is inhibited through binding to its inhibitor, IkappaB. Release of activated NF-kappaB follows proteasome-mediated degradation of IkappaBalpha resulting from phosphorylation of the inhibitor and finally conjugation with ubiquitin. We report that myeloma tumor cells show enhanced NF-kappaB activity. In addition, these patients possess polymorphisms of… CONTINUE READING

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