The role of notch in promoting glial and neural stem cell fates.

@article{Gaiano2002TheRO,
  title={The role of notch in promoting glial and neural stem cell fates.},
  author={Nicholas Gaiano and Gord Fishell},
  journal={Annual review of neuroscience},
  year={2002},
  volume={25},
  pages={
          471-90
        }
}
The Notch signaling pathway has long been known to influence cell fate in the developing nervous system. However, this pathway has generally been thought to inhibit the specification of certain cell types in favor of others, or to simply maintain a progenitor pool. Recently, this view has been challenged by numerous studies suggesting that Notch may play an instructive role in promoting glial development. This work has inspired a new look at the role of Notch signaling in specifying cell fate… 
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How a radial glial cell decides to become a multiciliated ependymal cell
TLDR
The role of two novel factors: McIdas and GemC1/Lynkeas and the molecular pathways which they activate in order to promote ependymal cell differentiation are highlighted and a possible crosstalk of known signaling pathways, such as Notch, STAT3, and BMPs, for the specification of ependedymal versus adult neural stem cells in the V‐SVZ niche is discussed.
Mapping spatio‐temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain
TLDR
Notch1 was transiently activated in the astrocytic lineage during perinatal CNS development and the present method has enabled to determine the timing, gradients, and boundaries of the activation of Notch signaling.
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References

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TLDR
It is suggested that Notch1 promotes radial glial identity during embryogenesis, and that radial glia may be lineally related to stem cells in the adult nervous system.
Notch signaling represses the glial fate in fly PNS.
TLDR
It is shown in vivo that glial cells are produced at the expense of neurons in the peripheral nervous system of flies lacking Notch and that constitutively activated Notch produces the opposite phenotype.
A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions.
TLDR
It is demonstrated that the SPGs share direct sibling relationships with neurones and are the products of asymmetric divisions, and it is shown that Notch signalling positively regulates glial cells missing (gcm) expression in the context of SPG development.
Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells
TLDR
It is shown that Notch ligands, which are normally expressed on differentiating neuroblasts, can inhibit neurogenesis in NCSCs in a manner that is completely dominant to BMP2, and this data suggest that Notches expressed by neuroblast may act positively to instruct a cell-heritable switch to gliogenesis in neighboring stem cells.
Glial growth factor restricts mammalian neural crest stem cells to a glial fate
TLDR
It is shown that glial growth factor (GGF), previously defined as a Schwann cell mitogen, strongly suppresses neuronal differentiation of rat neural crest stem cells while promoting or allowing glial differentiation.
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TLDR
It is demonstrated that a dominant gain-of-function mutant of mNotch suppresses neurogenesis, as well as myogenesis in P19 cells, and suggests that m notch may play a similar role in the choice of fate in the developing mammalian embryo.
Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate
TLDR
Evidence is presented that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat adult hippocampus-derived multipotent progenitors (AHPs) and quantitative clonal analysis indicates that the action of Notch is likely to be instructive.
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TLDR
The Gal4-UAS technique has been used to misexpress a constitutively active Notch receptor variant (notch1a-intra) in the developing zebrafish retina, and results strongly suggest that Notch 1a instructs a certain cell population to enter gliogenesis, and keeps the remaining cells in an undifferentiated state.
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  • Julian Lewis
  • Medicine, Biology
    Current Opinion in Neurobiology
  • 1996
The neurogenic genes of the Delta-Notch signalling pathway mediate lateral inhibition--a mechanism that controls cell commitment in many tissues and serves in the developing nervous system to single
Glide directs glial fate commitment and cell fate switch between neurones and glia.
TLDR
It is shown that the absence of glial cells is the consequence of a cell fate switch from glia to neurones, which suggests the existence of a multipotent precursor cells in the nervous system.
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