The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells.

Abstract

OBJECTIVES The purpose of this study was to investigate the effects of Noggin on high glucose-induced apoptosis and insulin secretion in pancreatic beta cells. MATERIALS AND METHODS Different concentrations of glucose were used to examine their effects on INS-1 rat beta cells in vitro. When specific siRNA targeting Noggin and recombinant Noggin were added… (More)

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