The role of nitric oxide on endothelial function.

  title={The role of nitric oxide on endothelial function.},
  author={Dimitris Tousoulis and Anna-Maria Kampoli and Costas Tentolouris and Nikolaos Papageorgiou and Christodoulos Stefanadis},
  journal={Current vascular pharmacology},
  volume={10 1},
The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme nitric oxide synthase (NOS). This substance has a wide range of biological properties that maintain vascular homeostasis, including modulation of vascular dilator tone, regulation of local cell growth, and protection of… CONTINUE READING