The role of nitric oxide on DNA damage induced by benzene metabolites.

@article{Melikian2008TheRO,
  title={The role of nitric oxide on DNA damage induced by benzene metabolites.},
  author={Assieh A. Melikian and Kun-ming Chen and Heyi Li and Rama S. Sodum and Emerich S. Fiala and Karam El-Bayoumy},
  journal={Oncology reports},
  year={2008},
  volume={19 5},
  pages={
          1331-7
        }
}
Benzene, a tobacco constituent, is a leukemogen in humans and a carcinogen in rodents. Several benzene metabolites generate superoxide anion (O(2)(.-)) and induce nitric oxide synthase in the bone marrow of mice. We hypothesized that the reaction of nitric oxide (*NO) with O(2)(.-) leads to the formation of peroxynitrite as an intermediate during benzene metabolism. This hypothesis was supported by demonstrating that the exposure of mice to benzene produced nitrated metabolites and enhanced the… CONTINUE READING

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