The role of nitric oxide in the pathogenesis of Chagas disease.


In this chapter we summarize the protective and toxic effects of nitric oxide (NO) that are frequently seen in parallel during the infection with Trypanosoma cruzi. The killing of trypomastigotes is dependent on the production of NO which is catalyzed by the inducible NO synthase (iNOS). The cytokines IFN-gamma and TNF-alpha and several chemoatractants… (More)


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