The role of nitric oxide in the innate resistance to microfilariae of Litomosoides sigmodontis in mice.

@article{Pfaff2000TheRO,
  title={The role of nitric oxide in the innate resistance to microfilariae of Litomosoides sigmodontis in mice.},
  author={Alexander W. Pfaff and Hartwig Schulz-Key and Peter T Soboslay and Stefan Michael Geiger and Wolfgang H. Hoffmann},
  journal={Parasite immunology},
  year={2000},
  volume={22 8},
  pages={397-405}
}
Nitric oxide (NO) has been shown to be an important effector mechanism in the defence against various pathogens, including filariae. The production of NO, as well as H2O2, is induced by the Th1 cytokine IFN-gamma. Therefore, the microfilariae (mf) of filarial nematodes, which are known to elicit the release of IFN-gamma, may be a target of NO release. In this study, we found that mf of the filarial species Litomosoides sigmodontis were resistant to the attack of H2O2, but vulnerable to NO… CONTINUE READING

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