The role of nitric oxide in serotonin-induced relaxations in the canine terminal ileum and ileocolonic junction

@article{Bogers1991TheRO,
  title={The role of nitric oxide in serotonin-induced relaxations in the canine terminal ileum and ileocolonic junction},
  author={J. Bogers and Paul A. Pelckmans and Guy E. E. Boeckxstaens and Joris G. De Man and Arnold G. Herman and Yvan M. van Maercke},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1991},
  volume={344},
  pages={716-719}
}
The role of nitric oxide (NO) in 5-HT-induced non-adrenergic non-cholinergic (NANC) relaxations was studied on circular muscle strips of the canine ileocolonic junction (ICJ) and terminal ileum. During an acetylcholine-induced contraction, NO (10−5 M) evoked a transient relaxation, whereas 5-HT (10−4 M) caused an initial NANC relaxation followed by a contraction. This initial relaxation to 5-HT, but not the relaxation to NO, was significantly inhibited by the stereospecific inhibitors of the NO… CONTINUE READING

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During an acetylcholine - induced contraction , NO ( 10−5 M ) evoked a transient relaxation , whereas 5-HT ( 10−4 M ) caused an initial NANC relaxation followed by a contraction .
During an acetylcholine - induced contraction , NO ( 10−5 M ) evoked a transient relaxation , whereas 5-HT ( 10−4 M ) caused an initial NANC relaxation followed by a contraction .
AcetylcholineSibling in is aSerotonin
During an acetylcholine - induced contraction , NO ( 10−5 M ) evoked a transient relaxation , whereas 5-HT ( 10−4 M ) caused an initial NANC relaxation followed by a contraction .
SerotoninSibling in is aAcetylcholine
During an acetylcholine - induced contraction , NO ( 10−5 M ) evoked a transient relaxation , whereas 5-HT ( 10−4 M ) caused an initial NANC relaxation followed by a contraction .
Larginine , but not D - arginine , prevented the inhibitory effect of L - NMMA and LNNA .
Larginine , but not D - arginine , prevented the inhibitory effect of L - NMMA and LNNA .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
Larginine , but not D - arginine , prevented the inhibitory effect of L - NMMA and LNNA .
Larginine , but not D - arginine , prevented the inhibitory effect of L - NMMA and LNNA .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
This initial relaxation to 5-HT , but not the relaxation to NO , was significantly inhibited by the stereospecific inhibitors of the NO biosynthesis NG - monomethyl - Larginine ( L - NMMA ) and NG - nitro - Irarginine ( L - NNA ) .
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