The role of nitric oxide in multiple sclerosis.

  title={The role of nitric oxide in multiple sclerosis.},
  author={Kenneth J. Smith and Hans Lassmann},
  journal={The Lancet. Neurology},
  volume={1 4},
Nitric oxide (NO) is a free radical found at higher than normal concentrations within inflammatory multiple sclerosis (MS) lesions. These high concentrations are due to the appearance of the inducible form of nitric oxide synthase (iNOS) in cells such as macrophages and astrocytes. Indeed, the concentrations of markers of NO production (eg, nitrate and nitrite) are raised in the CSF, blood, and urine of patients with MS. Circumstantial evidence suggests that NO has a role in several features of… CONTINUE READING
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