The role of nitric oxide in diabetes-induced changes of morphine tolerance in rats.

@article{Joharchi2007TheRO,
  title={The role of nitric oxide in diabetes-induced changes of morphine tolerance in rats.},
  author={Khojasteh Joharchi and Masoumeh Jorjani},
  journal={European journal of pharmacology},
  year={2007},
  volume={570 1-3},
  pages={66-71}
}
Several neuroendocrine complications including diabetes change the morphine antinociception and the development of tolerance to the drug. Morphine antinociception was reduced significantly in morphine tolerant diabetic rats compared to the non-diabetic animals. The exact mechanism of this effect is not known. This study was performed to determine the role of nitric oxide (NO) on morphine tolerance in diabetic state. Nociceptive responses in alloxan-induced diabetic morphine tolerated rats were… CONTINUE READING

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