The role of nicotinic acetylcholine receptors in Alzheimer’s disease

@article{Oddo2006TheRO,
  title={The role of nicotinic acetylcholine receptors in Alzheimer’s disease},
  author={Salvatore Oddo and Frank M. Laferla},
  journal={Journal of Physiology-Paris},
  year={2006},
  volume={99},
  pages={172-179}
}
The two hallmark lesions of Alzheimer's disease (AD) are extracellular amyloid plaques, mainly formed by a small peptide called amyloid-beta (Abeta), and neurofibrillary tangles, which are intracellular inclusions formed by aggregates of hyperphosphorylated tau protein. One of the major neurochemical features of AD is the marked reduction of nicotinic acetylcholine receptors in disease-relevant brain regions such as the cerebral cortex and hippocampus. This loss is further compounded by the… CONTINUE READING
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