The role of neutrophils in immune dysfunction during severe inflammation.

  title={The role of neutrophils in immune dysfunction during severe inflammation.},
  author={Pieter H C Leliefeld and Catharina M Wessels and Luke P H Leenen and Leo Koenderman and Janesh Pillay},
  journal={Critical care},
Critically ill post-surgical, post-trauma and/or septic patients are characterised by severe inflammation. This immune response consists of both a pro- and an anti-inflammatory component. The pro-inflammatory component contributes to (multiple) organ failure whereas occurrence of immune paralysis predisposes to infections. Strikingly, infectious complications arise in these patients despite the presence of a clear neutrophilia. We propose that dysfunction of neutrophils potentially increases… CONTINUE READING
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