The role of neutralizing antibody and T-helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV-1 challenge.

@article{Ghiasi1998TheRO,
  title={The role of neutralizing antibody and T-helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV-1 challenge.},
  author={Homayon Ghiasi and Steven L Wechsler and Steve Cai and Anthony B. Nesburn and Florence M. Hofman},
  journal={Immunology},
  year={1998},
  volume={95 3},
  pages={352-9}
}
In order to determine the possible correlation of specific immune responses with protection against mortality and ocular disease following ocular herpes simplex virus type 1 (HSV-1) challenge, BALB/c mice were vaccinated with different doses and regimens of baculovirus-expressed gD. Neutralizing antibody, virus titres in the eyes, corneal scarring, and survival were measured. In addition, infiltration into the cornea of CD4+ T cells and cells containing the lymphokines interleukin-2 (IL-2), IL… CONTINUE READING

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