The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development.

@article{Finke2003TheRO,
  title={The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development.},
  author={Daniela Finke and Sanjiv A Luther and Hans Acha-Orbea},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 1},
  pages={
          199-204
        }
}
Mouse mammary tumor virus (MMTV) infection establishes chronic germinal centers and a lifelong neutralizing Ab response. We show that removal of the draining lymph node after establishment of the germinal center reaction led to complete loss of neutralizing Abs despite comparable infection levels in peripheral lymphocytes. Importantly, in the absence of neutralization, only the exocrine organs mammary gland, salivary gland, pancreas, and skin showed strikingly increased infection, resulting in… CONTINUE READING