The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

@article{Pisciotta2007TheRO,
  title={The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.},
  author={John M. Pisciotta and I. Coppens and A. Tripathi and P. Scholl and J. Shuman and S. Bajad and V. Shulaev and D. Sullivan},
  journal={The Biochemical journal},
  year={2007},
  volume={402 1},
  pages={
          197-204
        }
}
The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin is degraded. Haem crystallization is the target of the widely used antimalarial quinoline drugs. The intracellular mechanism of molecular initiation of haem crystallization, whether by proteins, polar membrane lipids or by neutral lipids, has not been fully substantiated. In the present study, we show neutral lipid predominant nanospheres, which… Expand
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