The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling.

@article{Coulson2004TheRO,
  title={The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling.},
  author={Elizabeth J. Coulson and Kate Emily Reid and Kylie Shipham and Samantha Morley and Trevor J. Kilpatrick and Perry F. Bartlett},
  journal={Progress in brain research},
  year={2004},
  volume={146},
  pages={
          41-62
        }
}
The role of p75 neurotrophin receptor (p75NTR) in mediating cell death is now well characterized, however, it is only recently that details of the death signaling pathway have become clearer. This review focuses on the importance of the juxtamembrane Chopper domain region of p75NTR in this process. Evidence supporting the involvement of K+ efflux, the apoptosome (caspase-9, apoptosis activating factor-1, APAF-1, and Bcl-xL), caspase-3, c-jun kinase, and p53 in the p75NTR cell death pathway is… CONTINUE READING

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