The role of neuropilins in cell signalling.

@article{Zachary2009TheRO,
  title={The role of neuropilins in cell signalling.},
  author={Ian C Zachary and Paul Frankel and Ian M. Evans and Caroline Pellet-Many},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 6},
  pages={
          1171-8
        }
}
NRPs (neuropilins) are receptors for class 3 semaphorins, polypeptides essential for axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines. While mutant mouse studies show that NRP1 is essential for neuronal and cardiovascular development, little is known concerning the molecular mechanisms through which NRPs mediate the functions of their ligands in different cell types. NRP1 forms complexes with its co-receptors and is required for… CONTINUE READING

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