The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation.

@article{Somalwar2017TheRO,
  title={The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation.},
  author={Amita R. Somalwar and Gajanan P Shelkar and Nishikant K. Subhedar and Dadasaheb M Kokare},
  journal={Behavioural brain research},
  year={2017},
  volume={317},
  pages={340-349}
}
Rats with electrode implanted in the lateral hypothalamus (LH)-medial forebrain bundle (MFB) area actively engage in intracranial self-stimulation (ICSS). However, the neuronal substrate that translates the electrical pulses into the neural signals, and integrates the information with mesolimbic reward system, has remained elusive. We test the hypothesis that the cocaine- and amphetamine-regulated transcript (CART) neurons in the LH-MFB area may support this function. The ICSS activity via an… CONTINUE READING
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