The role of neural activity in synaptic development and its implications for adult brain function.

@article{Aamodt1999TheRO,
  title={The role of neural activity in synaptic development and its implications for adult brain function.},
  author={Stephanie Aamodt and Martha Constantine-Paton},
  journal={Advances in neurology},
  year={1999},
  volume={79},
  pages={133-44}
}
In much of the developing nervous system, electrical activity guides the formation of neural connections, with lasting effects on adult brain function. Epilepsy, a defect in neuronal excitability, might result from abnormal patterns of activity in the young brain. Many connections are organized by selective stabilization of synapses when they are activated simultaneously on the same postsynaptic cell during a sensitive period in early life. This process often involves calcium entry through the… CONTINUE READING

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This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
In these cultures , chronic depolarization and glutamate or NMDA treatment induces more mature NMDA receptor subunit expression patterns and function and also increases the expression of several gamma - aminobutyric acid type A ( GABAA ) receptor subunits , changing that receptor 's function .
In these cultures , chronic depolarization and glutamate or NMDA treatment induces more mature NMDA receptor subunit expression patterns and function and also increases the expression of several gamma - aminobutyric acid type A ( GABAA ) receptor subunits , changing that receptor 's function .
This process often involves calcium entry through the N - methyl - D - aspartate ( NMDA ) subtype of glutamate receptor .
During the formation of topographic connections between the retina and superior colliculus ( SC ) of young rats , chronic local application of the competitive NMDA receptor antagonist + 2-amino-5-phosphonovalerate ( D - APV ) blocks the normal developmental up - regulation of NMDA receptor subunit 1 ( NR1 ) mRNA and nitric oxide synthase activity , as well as maturation of calcium and calmodulin - dependent kinase distribution , activity , and substrate phosphorylation .
In these cultures , chronic depolarization and glutamate or NMDA treatment induces more mature NMDA receptor subunit expression patterns and function and also increases the expression of several gamma - aminobutyric acid type A ( GABAA ) receptor subunits , changing that receptor 's function .
Thus , the replacement of NMDA receptors that flux large calcium currents during early periods of synaptic organization with NMDA receptor subtypes that flux less calcium as synapses become more active , more effective , and less plastic allows maturing neurons to maintain optimal levels of intracellular calcium in the face of drastic developmental changes in their inputs .
Thus , the replacement of NMDA receptors that flux large calcium currents during early periods of synaptic organization with NMDA receptor subtypes that flux less calcium as synapses become more active , more effective , and less plastic allows maturing neurons to maintain optimal levels of intracellular calcium in the face of drastic developmental changes in their inputs .
During the formation of topographic connections between the retina and superior colliculus ( SC ) of young rats , chronic local application of the competitive NMDA receptor antagonist + 2-amino-5-phosphonovalerate ( D - APV ) blocks the normal developmental up - regulation of NMDA receptor subunit 1 ( NR1 ) mRNA and nitric oxide synthase activity , as well as maturation of calcium and calmodulin - dependent kinase distribution , activity , and substrate phosphorylation .
In these cultures , chronic depolarization and glutamate or NMDA treatment induces more mature NMDA receptor subunit expression patterns and function and also increases the expression of several gamma - aminobutyric acid type A ( GABAA ) receptor subunits , changing that receptor 's function .
During the formation of topographic connections between the retina and superior colliculus ( SC ) of young rats , chronic local application of the competitive NMDA receptor antagonist + 2-amino-5-phosphonovalerate ( D - APV ) blocks the normal developmental up - regulation of NMDA receptor subunit 1 ( NR1 ) mRNA and nitric oxide synthase activity , as well as maturation of calcium and calmodulin - dependent kinase distribution , activity , and substrate phosphorylation .
Thus , the replacement of NMDA receptors that flux large calcium currents during early periods of synaptic organization with NMDA receptor subtypes that flux less calcium as synapses become more active , more effective , and less plastic allows maturing neurons to maintain optimal levels of intracellular calcium in the face of drastic developmental changes in their inputs .
Thus , the replacement of NMDA receptors that flux large calcium currents during early periods of synaptic organization with NMDA receptor subtypes that flux less calcium as synapses become more active , more effective , and less plastic allows maturing neurons to maintain optimal levels of intracellular calcium in the face of drastic developmental changes in their inputs .
During the formation of topographic connections between the retina and superior colliculus ( SC ) of young rats , chronic local application of the competitive NMDA receptor antagonist + 2-amino-5-phosphonovalerate ( D - APV ) blocks the normal developmental up - regulation of NMDA receptor subunit 1 ( NR1 ) mRNA and nitric oxide synthase activity , as well as maturation of calcium and calmodulin - dependent kinase distribution , activity , and substrate phosphorylation .
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