The role of myeloid cells in cancer therapies

@article{Engblom2016TheRO,
  title={The role of myeloid cells in cancer therapies},
  author={Camilla Engblom and Christina Pfirschke and Mikael J. Pittet},
  journal={Nature Reviews Cancer},
  year={2016},
  volume={16},
  pages={447-462}
}
Recent clinical trials have demonstrated the ability to durably control cancer in some patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer treatment but benefit only a minority of patients. It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells… 
View on Nature
csb.mgh.harvard.edu
441 Citations
Highly Influential Citations
12
Background Citations
183
Methods Citations
3
Results Citations
3

441 Citations

Myeloid cell heterogeneity in cancer: not a single cell alike.

Myeloid Immune Cells CARrying a New Weapon Against Cancer

The elements that constitute the tumor microenvironment, the features and advantages of these cell subtypes and the latest studies using CAR-myeloid immune cells in solid tumor models are discussed.

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes. These…

Evolution and Targeting of Myeloid Suppressor Cells in Cancer: A Translational Perspective

This work reviews the current knowledge on the events governing protumoral myelopoiesis, analyzing the mechanisms that drive the expansion of major myeloid subsets, as well as their functional properties, and highlighting recent translational strategies for clinical developments.

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies are summarized, and the therapeutic potential of targeting TAMs as an adjuvant therapy in tumor immunotherapies is discussed.

Myeloid cell-targeted therapies for solid tumours.

Key features of monocyte and macrophage biology that are being explored as potential targets for cancer therapies are highlighted and what aspects of myeloid cells need a deeper understanding to identify rational combinatorial strategies to improve clinical outcomes of patients with cancer are highlighted.

Allies or Enemies—The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment

How distinct myeloid cell types can act as enemies of cancer cells by inducing or enhancing an existing immune response, while others act as strong allies, supporting tumor cells in their malignant growth and establishing an immune evasive TME is described.

Cancer-Host Interactions Influencing Disease Progression and Therapy

This work investigated long-range interactions between lung tumors and the bone, and newly link bone marrow stromal cells to distant tumor outgrowth via the production of bone marrowderived cells.

Role and Therapeutic Implications of MDSCs in Sarcomas

The known role of myeloid-derived suppressor cells (MDSCs) in creating an immunosuppressive state in the tumor microenvironment is explored and current issues with properly defining this heterogeneous continuum of cells with apparent context dependent phenotypic plasticity are highlighted.

The role of dendritic cells in cancer.

...

References

SHOWING 1-10 OF 269 REFERENCES

Macrophages and therapeutic resistance in cancer.

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected.

The most pertinent and controversial issues of MDSC biology and their role in promoting cancer progression are discussed and how these cells may be used in the clinic, both as prognostic factors and as therapeutic targets are highlighted.

Tumor-associated macrophages: from mechanisms to therapy.

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.

Role of macrophage targeting in the antitumor activity of trabectedin.

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

It is demonstrated that neutrophil-derived leukotrienes aid the colonization of distant tissues by selectively expanding the sub-pool of cancer cells that retain high tumorigenic potential and the efficacy of using targeted therapy against a specific tumour microenvironment component is revealed.

Cancer immunotherapy via dendritic cells

Dendritic cells are an essential target in efforts to generate therapeutic immunity against cancer owing to their ability to control both immune tolerance and immunity.

Immunogenic cell death in cancer therapy.

It is postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies and its subversion by pathogens.

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

The mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy is identified, pointing to new candidate targets for immune potentiation.

Trial watch: Dendritic cell-based anticancer therapy

Recent advances in the preclinical and clinical development of DC-based anticancer therapeutics are summarized.
...