The role of myeloid cells in cancer therapies

@article{Engblom2016TheRO,
  title={The role of myeloid cells in cancer therapies},
  author={Camilla Engblom and Christina Pfirschke and Mikael J. Pittet},
  journal={Nature Reviews Cancer},
  year={2016},
  volume={16},
  pages={447-462}
}
Recent clinical trials have demonstrated the ability to durably control cancer in some patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer treatment but benefit only a minority of patients. It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells… Expand
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Institut du Cancer de Montpellier - Val d'Aurelle
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References

SHOWING 1-10 OF 270 REFERENCES
Macrophages and therapeutic resistance in cancer.
TLDR
This review discusses the molecular/cellular pathways identified so far whereby macrophages mediate therapeutic responses and therapeutics impacting macrophage presence and/or bioactivity have shown promise in preclinical models and are now being evaluated in the clinic. Expand
The future of immune checkpoint therapy
TLDR
The way forward for this class of novel agents lies in the ability to understand human immune responses in the tumor microenvironment, which will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients. Expand
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected.
TLDR
The most pertinent and controversial issues of MDSC biology and their role in promoting cancer progression are discussed and how these cells may be used in the clinic, both as prognostic factors and as therapeutic targets are highlighted. Expand
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.
TLDR
It is shown that autochthonous tumors that lacked T-cell infiltration and resisted current treatment options could be successfully sensitized to host antitumor T cell immunity when appropriately selected immunogenic drugs were used. Expand
Tumor-associated macrophages: from mechanisms to therapy.
TLDR
Therapeutic success in targeting these protumoral roles in preclinical models and in early clinical trials suggests that macrophages are attractive targets as part of combination therapy in cancer treatment. Expand
Role of macrophage targeting in the antitumor activity of trabectedin.
TLDR
It is demonstrated that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusively in mononuclear phagocytes, and this unexpected property may be exploited in different therapeutic strategies. Expand
Neutrophils support lung colonization of metastasis-initiating breast cancer cells
TLDR
It is demonstrated that neutrophil-derived leukotrienes aid the colonization of distant tissues by selectively expanding the sub-pool of cancer cells that retain high tumorigenic potential and the efficacy of using targeted therapy against a specific tumour microenvironment component is revealed. Expand
Cancer immunotherapy via dendritic cells
TLDR
Dendritic cells are an essential target in efforts to generate therapeutic immunity against cancer owing to their ability to control both immune tolerance and immunity. Expand
The Emerging Understanding of Myeloid Cells as Partners and Targets in Tumor Rejection
TLDR
The hypothesis that the antigen-presenting compartment within tumor microenvironments may contain significant numbers of potent allies to be leveraged for immune-based tumor clearance is advanced. Expand
Immunogenic cell death in cancer therapy.
TLDR
It is postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies and its subversion by pathogens. Expand
...
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5
...