The role of myelin P2 protein in the production of experimental allergic neuritis.

@article{Rostami1984TheRO,
  title={The role of myelin P2 protein in the production of experimental allergic neuritis.},
  author={Abdolmohamad M. Rostami and Mark D. J. Brown and Robert P. Lisak and Austin J. Sumner and Burton Zweiman and David Pleasure},
  journal={Annals of neurology},
  year={1984},
  volume={16 6},
  pages={680-5}
}
Myelin P2 protein has been proposed as the primary antigen in whole myelin-induced experimental allergic neuritis (EAN). We investigated the neuritogenic properties of P2 by sensitizing Lewis rats with complete Freund's adjuvant (CFA) containing P2, P2 plus phosphatidyl serine, or whole myelin containing an equivalent amount of P2. Animals were examined using a battery of clinical, electrophysiological, immunological, and morphological methods. Myelin-immunized rats developed the characteristic… CONTINUE READING