The role of mutant p53 in human cancer

  title={The role of mutant p53 in human cancer},
  author={A. M. Goh and C. R. Coffill and D. Lane},
  journal={The Journal of Pathology},
  • A. M. Goh, C. R. Coffill, D. Lane
  • Published 2011
  • Biology, Medicine
  • The Journal of Pathology
  • Mutations in the TP53 (p53) gene are present in a large fraction of human tumours, which frequently express mutant p53 proteins at high but heterogeneous levels. The clinical significance of this protein accumulation remains clouded. Mouse models bearing knock‐in mutations of p53 have established that the mutant p53 proteins can drive tumour formation, invasion and metastasis through dominant negative inhibition of wild‐type p53 as well as through gain of function or ‘neomorphic’ activities… CONTINUE READING
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