Corpus ID: 25967750

The role of mucosal mast cell degranulation and free-radical generation in intestinal ischaemia-reperfusion injury in rats.

@article{Kimura1998TheRO,
  title={The role of mucosal mast cell degranulation and free-radical generation in intestinal ischaemia-reperfusion injury in rats.},
  author={T. Kimura and Y. Fujiyama and M. Sasaki and A. Andoh and M. Fukuda and S. Nakajima and Tadao Bamba},
  journal={European journal of gastroenterology & hepatology},
  year={1998},
  volume={10 8},
  pages={
          659-66
        }
}
  • T. Kimura, Y. Fujiyama, +4 authors Tadao Bamba
  • Published 1998
  • Medicine
  • European journal of gastroenterology & hepatology
  • OBJECTIVES In this study, we determined the role of mucosal mast cell (MMC) activation in the pathogenesis of intestinal ischaemia-reperfusion (I/R) injury by immunohistochemical analysis using anti-RMCP II antibody. In addition, we investigated the role of free-radical generation in the activation of MMCs in this model. METHODS In the first experiment, rats were divided into four groups: (1) sham operated; (2) I/R + saline; (3) I/R + the mast cell stabilizer, MAR-99 (30 mg/kg); and (4) I/R… CONTINUE READING
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