The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry.


Protein A chromatography has been used as the mAb capture step in the majority of FDA submissions. In this study, the performance of protein A chromatography, as indicated by capacity, operational flow rate, and productivity (rate of mAb production per liter of resin) was examined over its full history to gain insights into the reasons for its consistent… (More)
DOI: 10.1002/btpr.2324