The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells.

@article{Wang2007TheRO,
  title={The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells.},
  author={Qi Wang and Marilyn E Morris},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 8},
  pages={1393-9}
}
Monocarboxylate transporter 1 (MCT1) is an important determinant of the renal transport of the drug of abuse, gamma-hydroxybutyric acid (GHB). The objective of this study was to investigate the role of MCT2 and MCT4, present in tissues including intestine, kidney, skeletal muscle, and brain, in the membrane transport of GHB and the MCT substrate l-lactate. mRNA and protein of MCT2 and MCT4 were expressed in MDA-MB231 cells, as detected by reverse transcription-polymerase chain reaction and… CONTINUE READING
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Characterisation of human monocar

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  • 2000
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