The role of monoamines for the central effects of Baclofen on behavior of rats

@article{Smith1979TheRO,
  title={The role of monoamines for the central effects of Baclofen on behavior of rats},
  author={Donald F. Smith and Peter Vestergaard},
  journal={Journal of Neural Transmission},
  year={1979},
  volume={46},
  pages={215-223}
}
Male albino rats given a bilateral injection of Baclofen (Lioresal®) (12μg/rat) in the cerebral ventricles showed a behavioral syndrome of activation+ataxia, paddling, tail-pinch hyperresponse and anesthesia. The phase of activation+ataxia was reduced by pretreatment of rats with H 44/68, FLA 63, reserpine, pimozide, phenoxybenzamine, oxypertine or chlorpromazine. The phase of paddling was reduced by pretreatment with FLA 63, reserpine, phenoxybenzamine, oxypertine, chlorpromazine, pimozide… CONTINUE READING

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