The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons.

@article{Gershkovich2009TheRO,
  title={The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons.},
  author={P. Gershkovich and Joseph Fanous and Bashir Qadri and A. Yacovan and S. Amselem and A. Hoffman},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 1},
  pages={
          31-9
        }
}
  • P. Gershkovich, Joseph Fanous, +3 authors A. Hoffman
  • Published 2009
  • Medicine
  • The Journal of pharmacy and pharmacology
  • OBJECTIVES The uptake of drugs by chylomicrons is a key element in both intestinal lymphatic transport and postprandial alterations in the disposition profile of lipophilic drugs. The aim of this article was to elucidate the factors that affect this phenomenon. METHODS The degree of association of 22 model lipophilic molecules with rat chylomicrons was assessed and correlated in silico with calculated physicochemical properties. The in-silico model was then validated using an external set of… CONTINUE READING
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