Corpus ID: 2145995

The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.

@article{Chen2003TheRO,
  title={The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.},
  author={Y. Chen and K. Alm and S. Vujcic and D. Kramer and K. Kee and P. Diegelman and C. Porter},
  journal={Cancer research},
  year={2003},
  volume={63 13},
  pages={
          3619-25
        }
}
  • Y. Chen, K. Alm, +4 authors C. Porter
  • Published 2003
  • Biology, Medicine
  • Cancer research
  • The clinically relevant polyamine analogue N(1),N(11)-diethylnorspermine (DENSPM) inhibits cell growth by down-regulating polyamine biosynthesis, up-regulating polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase (SSAT), and depleting intracellular polyamine pools. Among human melanoma cell lines, the analogue causes rapid apoptosis in SK-MEL-28 cells and a sharp G(1) arrest in MALME-3M cells. This study reveals that DENSPM potently activates the mitogen-activated… CONTINUE READING
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