The role of mitogen-activated protein (MAP) kinase in breast cancer

@article{Santen2002TheRO,
  title={The role of mitogen-activated protein (MAP) kinase in breast cancer},
  author={Richard Santen and Robert Xinde Song and Robert C. McPherson and Rakesh Kumar and Wei Yue},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2002},
  volume={80},
  pages={239-256}
}
Mitogen-activated protein kinase (MAP kinase) cascades transmit and amplify signals involved in cell proliferation as well as cell death. These signal transduction pathways serve as an indicators of the intensity of trafficking induced by various growth factor, steroid hormone, and G protein receptor mediated ligands. Three major MAP kinase pathways exist in human tissues, but the one involving ERK-1 and -2 is most relevant to breast cancer. Peptide growth factors acting through tyrosine kinase… CONTINUE READING
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