The role of mitochondrial potential in control of calcium signals involved in cell proliferation.

@article{Valero2008TheRO,
  title={The role of mitochondrial potential in control of calcium signals involved in cell proliferation.},
  author={Ruth Ana Valero and Laura Mu{\~n}oz Senovilla and Luc{\'i}a Gonz{\'a}lez N{\'u}{\~n}ez and Carlos Villalobos},
  journal={Cell calcium},
  year={2008},
  volume={44 3},
  pages={
          259-69
        }
}
Store-operated Ca2+ entry (SOCE), a Ca2+ influx pathway involved in cell proliferation, depends on mitochondrial Ca2+ uptake, a Ca2+ influx that is driven by the mitochondrial potential (DeltaPsi). Whereas much attention has been paid to the Ca2+-dependence of mitochondrial Ca2+ uptake, its dependence on DeltaPsi remains largely in qualitative terms. We have studied the dose-dependent effects of a mild mitochondrial uncoupler, salicylate, on DeltaPsi, mitochondrial Ca2+ concentration ([Ca2+]mit… CONTINUE READING
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