The role of mitochondrial oxidative stress in aging.

  title={The role of mitochondrial oxidative stress in aging.},
  author={Juan Sastre and Federico Vicente Pallard{\'o} and J. Vi{\~n}a},
  journal={Free radical biology & medicine},
  volume={35 1},
Mitochondria are both a major source of oxidants and a target for their damaging effects, and, therefore, mitochondrial oxidative stress appears to be a cause, rather than a consequence, of cell aging. Oxidative damage in aging is particularly high in specific molecular targets, such as mitochondrial DNA and aconitase, and mitochondrial oxidative stress may drive tissue aging through intrinsic apoptosis. Mitochondrial function and morphology are impaired upon aging, as judged by a decline in… CONTINUE READING
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