The role of mitochondrial glutathione in DNA base oxidation.

  title={The role of mitochondrial glutathione in DNA base oxidation.},
  author={Cecilia Giulivi and Enrique Cadenas},
  journal={Biochimica et biophysica acta},
  volume={1366 3},
The objective of this study was to elucidate the role of mitochondrial GSH in the reactions leading to mitochondrial DNA oxidative damage in terms of 8-hydroxy-desoxyguanosine (8-HOdG) accumulation. With this purpose, tightly coupled mitochondria depleted of matrix GSH were used and the effects of H2O2 (generated during the oxidation of substrates) on 8-HOdG levels were investigated. Mitochondrial integrity, assessed by O2 uptake, respiratory control and P/O ratios, was conserved upon depletion… CONTINUE READING
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