The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet

@article{Loo2002TheRO,
  title={The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet},
  author={G. C. van Loo and Xavier Saelens and Maria van Gurp and Marion Macfarlane and S J Martin and Peter Vandenabeele},
  journal={Cell Death and Differentiation},
  year={2002},
  volume={9},
  pages={1031-1042}
}
Mitochondria are ‘life-essential’ organelles for the production of metabolic energy in the form of ATP. Paradoxically mitochondria also play a key role in controlling the pathways that lead to cell death. This latter role of mitochondria is more than just a ‘loss of function’ resulting in an energy deficit but is an active process involving different mitochondrial proteins. Cytochrome c was the first characterised mitochondrial factor shown to be released from the mitochondrial intermembrane… CONTINUE READING
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