The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney.

@article{Plotnikov2007TheRO,
  title={The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney.},
  author={Egor Y Plotnikov and A. V. Kazachenko and Mikhail Yu Vyssokikh and A. K. Vasileva and D V Tcvirkun and Nikolay K. Isaev and V. I. Kirpatovsky and Dmitry B. Zorov},
  journal={Kidney international},
  year={2007},
  volume={72 12},
  pages={1493-502}
}
Reoxygenation following ischemia causes tissue oxidative stress. We studied the role of oxidative stress caused by kidney ischemia/reperfusion (I/R) on the mitochondria of renal tissue slices. I/R caused the mitochondria to be swollen, fragmented, and have lower membrane potential. The mitochondria generated more reactive oxygen species (ROS) and nitric oxide (NO) in situ as measured by fluorescence of ROS- and NO-sensitive probes. Infusion of lithium ion, an inhibitor of glycogen kinase… CONTINUE READING