The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

@article{Michels2015TheRO,
  title={The role of microglia activation in the development of sepsis-induced long-term cognitive impairment},
  author={Monique Michels and Andriele S. Vieira and Francieli Vuolo and Hugo Galvane Zapelini and Felipe Dal-Pizzol},
  journal={Brain, Behavior, and Immunity},
  year={2015},
  volume={43},
  pages={54-59}
}
Oxidative stress and inflammation is likely to be a major step in the development of sepsis-associated encephalopathy (SAE) and long-term cognitive impairment. To date, it is not known whether brain inflammation and oxidative damage are a direct consequence of systemic inflammation or whether these events are driven by brain resident cells, such as microglia. Therefore, the aim of this study is to evaluate the effect of minocycline on behavioral and neuroinflammatory parameters in rats… CONTINUE READING
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