The role of microRNAs in normal and malignant hematopoiesis

  title={The role of microRNAs in normal and malignant hematopoiesis},
  author={Diamantina Vasilatou and Sotirios G. Papageorgiou and Vassiliki Pappa and Efstathios Papageorgiou and John Dervenoulas},
  journal={European Journal of Haematology},
MicroRNAs are small non‐coding RNAs that act at the post‐transcriptional level, regulating protein expression by repressing translation or destabilizing mRNA target. Because of their discovery, microRNAs have been associated with almost every normal cell function, including proliferation, differentiation and apoptosis. Several lines of evidence suggest that they have an important role in normal hematopoiesis as exemplified by the role of mir‐155 and mir‐150 in the differentiation of B and T… 

Translation Regulation by microRNAs in Acute Leukemia

In this chapter, a summary is provided of the current knowledge regarding translation regulation exerted by miRNAs, modulations of their expression levels in acute leukemia types including acute myeloid leukemia, acute lymphoblastic leukemia and myelodysplastic syndrome.

Involvement of MicroRNA in T-Cell Differentiation and Malignancy

A review of studies in recent years on the role of miRNAs in T-cell development and their aberrant expression in pathogenesis of T- cell leukemia and lymphoma is presented.

MicroRNAs in B-cells: from normal differentiation to treatment of malignancies

The findings of miRNA studies in hematological cancers are summed up, from the development and progression of the disease to the response to treatment, with a particular emphasis on B-cell malignancies.

miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways

It is found that miR-150 is downregulated in samples from patients with acute lymphoblastic leukemia, acute myeloids leukemia, and chronic myeloid leukemia,and normalized after patients achieved complete remission, and provides a rationale for utilizing mi R-150 as a novel therapeutic agent for leukemia treatment.

Deregulated microRNAs in multiple myeloma

The authors describe the current knowledge on microRNA involvement in regulatory pathways that characterize multiple myeloma pathogenesis gained from in vitro and in vivo studies and suggest that microRNAs represent an attractive therapeutic target in the context of multipleMyeloma interfering with the myelomas regulatory networks.

The prognostic and functional role of microRNAs in acute myeloid leukemia.

It is reasonable to predict the development of novel microRNA-based therapeutic approaches in AML, and it has been demonstrated experimentally that antileukemic effects can be achieved by modulating microRNA expression by pharmacologic agents and/or increasing low endogenous levels of microRNAs with tumor suppressor function by synthetic microRNA oligonucleotides.

The Pivotal Role of microRNA‐155 in the Control of Cancer

The current knowledge on the functional role of miR‐155 in the control of various cancers is reviewed and silencing oncomiRs or gene therapy approaches could be an effective therapeutic approach against tumor.

Role of microRNA-150 in solid tumors (Review)

The aim of the present review was to summarize the current knowledge on the functions and regulatory mechanism of miR-150 as an oncogene or tumor suppressor gene in solid tumors and its potential application as a tumor biomarker, targeted therapeutic strategy and index of prognosis in various cancer types was investigated.

MicroRNAs in acute leukemia: from biological players to clinical contributors

This work comprehensively discusses miRNAs found discriminative for cytogenetic and molecular subtypes of acute leukemia and outlines forces that drive aberrant miRNA function, which include genetic abnormalities and epigenetic aberrations.



MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia

The expression of miRNAs in acute promyelocytic leukemia patients and cell lines during all-trans-retinoic acid (ATRA) treatment is reported by using a miRNA microarrays platform and quantitative real time–polymerase chain reaction (qRT–PCR).

miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia.

  • D. ZanetteF. Rivadavia M. Zago
  • Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2007
This initial screening provided information on miRNA differentially expressed in normal and malignant B-cells that could suggest the potential roles of these miRNAs in hematopoiesis and leukemogenesis.

MicroRNAs and haematology: small molecules, big function

  • C. Lawrie
  • Biology
    British journal of haematology
  • 2007
The rapidly accumulating research that points to the major role microRNAs play in both haem atopoiesis and haematological malignancy is discussed.

c-Myc-regulated microRNAs modulate E2F1 expression

A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed.

MicroRNAs in the ontogeny of leukemias and lymphomas

Intriguingly, some of the miRNA-expression abnormalities described in leukemias and lymphomas can be interpreted on the basis of theMiRNome variations during normal hematologic ontogeny, revealing their origin from the particular differentiation stage in which the hematopoietic differentiation has been ‘frozen’ in the malignancy.

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.

The results of this study offer for the first time a comprehensive and quantitative profile of miRNA expression in CLL and their healthy counterpart, suggesting that miRNAs could play a primary role in the disease itself.

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

Evidence is presented of a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide correlated with granulocyte/monocyte (GM) expansion, which implicate mi R-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML.

MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis

It is shown that the decline of miR-223 is an important event for erythroid differentiation that leads to the expansion of erythroblast cells at least partially mediated by unblocking LMO2 protein expression.