The role of microRNAs in colorectal cancer.

  title={The role of microRNAs in colorectal cancer.},
  author={Aaron J. Schetter and Hirokazu Okayama and Curtis C. Harris},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  volume={37 6},
During the last decade, it has become clear that aberrant microRNA expression has a functional role in the initiation and progression of colorectal cancer (CRC). Specific microRNAs can act as either tumor suppressors or oncogenes depending on the cellular environment in which they are expressed. The expression of microRNAs is reproducibly altered in CRC, and their expression patterns are associated with diagnosis, prognosis, and therapeutic outcome in CRC. Studies have begun to examine the… CONTINUE READING