The role of methylation in CML.

  title={The role of methylation in CML.},
  author={Eliezer A. Rachmilewitz},
  journal={Przeglad lekarski},
  volume={57 Suppl 1},
Methylation of the proximal promoter of the ABL1 oncogene is common epigenetic alteration associated with clinical progression of chronic myeloid leukemia (CML). In presented study we queried whether both the Ph'-associated and normal ABL1 alleles undergo methylation; what may be the proportion of hematopoietic progenitors bearing methylated ABL1 promoters in chronic versus acute phase disease; whether methylation affects the promoter uniformly or in patches with discrete clinical relevance… CONTINUE READING