The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.

@article{Verloes2017TheRO,
  title={The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.},
  author={A. Verloes and Claudia Spits and Martine J Vercammen and Mieke Geens and Jo{\"e}l Lemaoult and Karen Dora Sermon and Wim Coucke and Hilde van de Velde},
  journal={Stem cell research},
  year={2017},
  volume={19},
  pages={118-127}
}
The human leukocyte antigen (HLA)-G gene seems to play a pivotal role in maternal tolerance to the fetus. Little is known about HLA-G expression and its molecular control during in vivo human embryogenesis. Human embryonic stem cells (hESC) provide an interesting in vitro model to study early human development. Different studies reported discrepant findings on whether HLA-G mRNA and protein are present or absent in hESC. Several lines of evidence indicate that promoter CpG methylation and 3… CONTINUE READING
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