The role of methadone in cancer pain treatment – a review
@article{Leppert2009TheRO, title={The role of methadone in cancer pain treatment – a review}, author={Wojciech Leppert}, journal={International Journal of Clinical Practice}, year={2009}, volume={63} }
Background: Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder.
75 Citations
The role of methadone in cancer-induced bone pain: a retrospective cohort study
- Medicine, PsychologySupportive Care in Cancer
- 2020
MR for CIBP may result in reduction in pain intensity, when other opioids are ineffective or intolerable, with patients requiring reduced overall dosing of their long-acting opioid and frequency of breakthrough opioid use.
Methadone for Pain Management in Children with Cancer
- MedicinePediatric Drugs
- 2018
There is support for the safety and efficacy of methadone in treating pain in children with cancer, particularly when pain is refractory to conventional treatment, but further evaluation with prospective studies is warranted to develop evidence-based recommendations.
[Use of methadone in the elderly with cancer pain: a systematic review].
- MedicineRevista espanola de geriatria y gerontologia
- 2014
Early Use of Methadone for Cancer Pain
- Medicine
- 2018
Methadone is a very interesting molecule for cancer pain treatment because of anti NMDA, SSRI and opioid actions, lack of active metabolite, and cost, but its benefits must be balanced against the potential drug to drug interactions during treatment initiation and interactions with other drugs when methadone doses are stable.
A Randomized Controlled Trial Evaluating the Analgesic Effect of the Combination of Methadone With Morphine for Cancer Related Pain
- MedicineThe Clinical journal of pain
- 2021
Low dose of methadone in combination with morphine provided faster pain control as compared to morphine alone, and although this study was not powered to show differences in adverse effects, the authors did not notice a difference.
The role of methadone in pain treatment in cancer patients
- Medicine, Psychology
- 2012
The mentioned advantages of methadone, especially high analgesic efficacy, low cost of the treatment and lack of significant immunosupressive effect causes that methamphetamineadone is an important alternative or complement to other opioids.
Methadone rotation for cancer pain: an observational study.
- MedicineBMJ supportive & palliative care
- 2020
Rotation to methadone according to the protocol is effective in achieving adequate analgesia in most patients experiencing nociceptive-neuropathic pain, and results suggest that a fixed equianalgesic ratio of 10:1 may be adequate for patients at low-to-moderate MEDD <400 mg/day.
Efficacy and Safety of Methadone as a Second-Line Opioid for Cancer Pain in an Outpatient Clinic: A Prospective Open-Label Study.
- MedicineThe oncologist
- 2016
The results of this study support the efficacy and safety of oral methadone as a second-line opioid in ambulatory patients with cancer and corroborate previously reported outcomes in retrospective outpatient studies and prospective studies that evaluated inpatient populations.
Methadone rotation for cancer patients with refractory pain in a palliative care unit: an observational study.
- Medicine, PsychologyJournal of palliative medicine
- 2013
The results suggest that methadone is effective and well tolerated for refractory cancer pain management in palliative care unit (PCU) inpatients.
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Patients often are rotated from other opioids to methadone when side effects occur before satisfactory analgesia is achieved, and there are no guidelines for estimating safe and effective starting doses of methad one when rotating from fentanyl.
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The purpose of this study was to determine the equianalgesic dose ratio between morphine and methadone in patients with cancer pain and to establish whether the dose ratio changes as a function of previous opioid dose.