The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.
@article{Block2017TheRO,
title={The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.},
author={Eric Block and Victor S. Batista and Hiroaki Matsunami and Hanyi Zhuang and Lucky Ahmed},
journal={Natural product reports},
year={2017},
volume={34 5},
pages={
529-557
}
}Covering: up to the end of 2017While suggestions concerning the possible role of metals in olfaction and taste date back 50 years, only recently has it been possible to confirm these proposals with experiments involving individual olfactory receptors (ORs). A detailed discussion of recent experimental results demonstrating the key role of metals in enhancing the response of human and other vertebrate ORs to specific odorants is presented against the backdrop of our knowledge of how the sense of…
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References
SHOWING 1-10 OF 219 REFERENCES
Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols.
- BiologyJournal of the American Chemical Society
- 2016
It is found that human thiol receptor OR2T11 responds specifically to gas odorants t-BuSH and EtSH requiring ionic copper for its robust activation and that this role of copper is mimicked by ionic and nanoparticulate silver.
Crucial role of copper in detection of metal-coordinating odorants
- BiologyProceedings of the National Academy of Sciences
- 2012
It is shown that copper ion among all metal ions tested is required for robust activation of MOR244-3 toward ppb levels of MTMT, structurally related sulfur compounds, and other metal-coordinating odorants among >125 compounds tested.
Fifty years of smelling sulfur: From the chemistry of garlic to the molecular basis for olfaction
- Biology, Chemistry
- 2017
It has been discovered that human thiol receptor OR2T11 responds specifically to gas odorants ethanethiol and 2-methyl-2-propanethiol, as well as to related low molecular weight thiols, and requires ionic copper for its robust activation.
Effects of continuous copper exposure and calcium on the olfactory response of fathead minnows.
- BiologyEnvironmental science & technology
- 2012
Safe copper concentrations as predicted by the gill-based Biotic Ligand Model, chemosensory-based BLMs, the USEPA BLM, and hardness-adjustment equations based on the exposure waters were not entirely protective against olfactory dysfunction.
Is the olfactory receptor a metalloprotein?
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2003
A hypothesis in which metal ions play an important role for odorant recognition is described and a “shuttlecock” mechanism for the possible structural change in ORs upon odorant binding is proposed, involving membrane penetration of the 4–5 loop after residue charge neutralization by metal ion binding.
Olfactory sensitivity for putrefaction-associated thiols and indols in three species of non-human primate
- BiologyJournal of Experimental Biology
- 2007
The results showed all three species of non-human primate to have a highly developed olfactory sensitivity for putrefaction-associated odorants, and a significant correlation between perceptibility in terms of o aroma detection threshold and carbon chain length of the thiols and a marked effect of the presence vs absence of a methyl group on perceptibility of the indols tested in two of the three species.
The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur
- Chemistry
- 1992
A Cook's tour is presented of the organosulfur chemistry of the genus Allium, as represented, inter alia, by garlic (Allium sativum L.) and onion (Allium cepa L.). We report on the biosynthesis of…
Nature's chemical signatures in human olfaction: a foodborne perspective for future biotechnology.
- BiologyAngewandte Chemie
- 2014
This perspective gives insight into nature's chemical signatures of smell, provides the chemical odor codes of more than 220 food samples, and beyond addresses industrial implications for producing recombinants that fully reconstruct the natural odor signatures for use in flavors and fragrances, fully immersive interactive virtual environments, or humanoid bioelectronic noses.
Honeybees (Apis mellifera) learn to discriminate the smell of organic compounds from their respective deuterated isotopomers
- BiologyProceedings of the Royal Society B: Biological Sciences
- 2014
Testing honeybees using the proboscis extension reflex learning in a differential conditioning paradigm shows that honeybees readily learn to discriminate hydrogen-based odorants from their deuterated counterparts and supports the idea that intra-molecular vibrations may contribute to odour discrimination.