The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.

@article{Marczyska2014TheRO,
  title={The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.},
  author={Joanna Marczyńska and Aleksandra Ozga and Agnieszka Wlodarczyk and Monika Majchrzak-Gorecka and Paulina Kulig and Magdalena Banaś and Dominika Michalczyk-Wetula and Pawel Majewski and Andreas Hutloff and Jeanette Schwarz and Athena Chalaris and J{\"u}rgen Scheller and Stefan Rose-John and Joanna Cichy},
  journal={Journal of immunology},
  year={2014},
  volume={193 6},
  pages={2753-63}
}
Immune cells regulate cell surface receptor expression during their maturation, activation, and motility. Although many of these receptors are regulated largely at the level of expression, protease-mediated ectodomain shedding represents an alternative means of refashioning the surface of immune cells. Shedding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metalloproteases, including ADAM17. Although ADAM17 is well known to contribute to the innate immune… CONTINUE READING