Corpus ID: 25196342

The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine.

@article{Midha1993TheRO,
  title={The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine.},
  author={K. Midha and J. W. Hubbard and G. McKay and E. Hawes and D. Hsia},
  journal={International journal of clinical pharmacology, therapy, and toxicology},
  year={1993},
  volume={31 4},
  pages={
          177-83
        }
}
  • K. Midha, J. W. Hubbard, +2 authors D. Hsia
  • Published 1993
  • Chemistry, Medicine
  • International journal of clinical pharmacology, therapy, and toxicology
  • Loxapine is a drug which is used in the treatment of psychotic disorders. The drug is extensively biotransformed in humans to produce a variety of metabolites, some of which have pharmacological activity. Seven-hydroxyloxapine is 4-5 times more active than the parent drug, although its concentrations in plasma are relatively low. Eight-hydroxyloxapine, on the other hand, is inactive, but is present in higher concentrations in plasma than the parent drug. In the present randomized crossover… CONTINUE READING
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