The role of metabolite-specific antibodies in nomifensine-dependent immune hemolytic anemia.

@article{Salama1985TheRO,
  title={The role of metabolite-specific antibodies in nomifensine-dependent immune hemolytic anemia.},
  author={Abdulagabar Salama and C. Mueller-Eckhardt},
  journal={The New England journal of medicine},
  year={1985},
  volume={313 8},
  pages={469-74}
}
Nomifensine is an antidepressant drug (widely used in Europe, but not yet available in the United States), which has been linked to intravascular hemolysis. We studied 19 patients (18 women and 1 man) with acute intravascular hemolysis due to nomifensine-dependent antibodies. Transitory renal insufficiency developed in at least seven patients, and four required temporary dialysis. To investigate the antibodies, we used nomifensine, its three main metabolites, and its ex vivo antigens (urine… CONTINUE READING