The role of melatonin in prevention of intestinal ischemia-reperfusion injury in rats.

@article{Kazez2000TheRO,
  title={The role of melatonin in prevention of intestinal ischemia-reperfusion injury in rats.},
  author={Ahmet Cihat Kazez and Mehmet Demirbag and Bilal Ust{\"u}ndağ and Ibrahim Hanifi Ozercan and Mutlu Sağlam},
  journal={Journal of pediatric surgery},
  year={2000},
  volume={35 10},
  pages={
          1444-8
        }
}
BACKGROUND/PURPOSE The aim of this study was to determine the effect of melatonin, a hormone that is known as an antioxidant, on the prevention of tissue damage during mesenteric ischemia/reperfusion (I/R). METHODS A total of 40 young Wistar-albino rats were divided equally into 4 groups with varied treatment. Group 1 was control (sham), group 2 was I/R, group 3 was I/R plus melatonin (10 mg/kg) and group 4 was I/R plus melatonin (20 mg/kg). I/R was realized as follows: after laparatomy, a… CONTINUE READING

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